A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria
نویسندگان
چکیده
منابع مشابه
SCREENING FOR ANTIBIOTIC RESISTANT BACTERIA IN URINE SAMPLES
Chronic urinary tract infections are often caused by antibiotic resistant bacteria. In some of these cases, prediction of the most effective antibiotic (s) may urgently be needed. This can not be achieved unless the nature and patterns of the resistance to antibiotics among the pathogenic bacteria has been described earlier. The urine samples that reached the laboratory of Shaheed Mustafa K...
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Screening of3000 soil samples collected from cities of four different provinces of Iran for starch-hydrolysing bacteria revealed that the nature is enriched with Streptomyces species capable of producing amylolytic enzymes. Among the bacterial isolates, one of the high starch-degrading strains was selected for further microbiological identification and also amylolytic enzyme(s) characteriza...
متن کاملscreening for antibiotic resistant bacteria in urine samples
chronic urinary tract infections are often caused by antibiotic resistant bacteria. in some of these cases, prediction of the most effective antibiotic (s) may urgently be needed. this can not be achieved unless the nature and patterns of the resistance to antibiotics among the pathogenic bacteria has been described earlier. the urine samples that reached the laboratory of shaheed mustafa khome...
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Fleming researchers have developed an actin-based cellular assay for drug discovery in treating Rheumatoid Arthritis (RA). The assay uses primary synovial fibroblasts (SF) isolated from the joints of proprietary arthritic transgenic mice overexpressing human TNF. The assay accurately quantifies the intracellular level of F-actin using fluorescencently-labelled phalloidin. Reduced F-actin levels...
متن کاملScreening for antibiotics active against intracellular bacteria.
A large number of useful antibiotics have been discovered since the isolation of tyrothricin in 1939, yet as time passes and as the number of known antibiotics increases, their rediscovery becomes more and more fre(uent. Improvements in screening techniques are therefore indicated to eliminate undesired antibiotics with a minimum of labor. New techniques should also attempt to recognize biologi...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2019
ISSN: 1548-7091,1548-7105
DOI: 10.1038/s41592-019-0333-y